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Natural Nutrition and Holistic Healthcare For Cats & Dogs and People, too! (818) 707-6331 / Fax (818) 707-6333 www.celestialpets.com * celestialpet@sbcglobal.net
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Microchipping,
Malignancies At Implantation Sites
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| Tumors
surrounding implanted microchip animal identification devices were noted
in two separate chronic toxicity/oncogenicity studies using F344 rats. The
tumors occurred at a low incidence rate (approximately 1 percent), but did
result in the early sacrifice of most affected animals, due to tumor size
and occasional metastases. No sex-related trends were noted. All tumors
occurred during the second year of the studies, were located in the subcutaneous
dorsal thoracic area (the site of microchip implantation) and contained
embedded microchip devices. All were esenchymal in origin and consisted
of the following types, listed in order of frequency: malignant schwannoma,
fibrosarcoma, anaplastic sarcoma, and histiocytic sarcoma. The following
diagnostic techniques were employed: light microscopy, scanning electron
microscopy, and immunohistochemistry. The mechanism of carcinogenicity appeared
to be that of foreign-body induced tumorigenesis. PMID: 11256750
[PubMed - indexed for EDLINE] |
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Related Links: Subcutaneous microchip-associated tumours in B6C3F1 mice: a retrospective study to attempt to determine their histogenesis. [Exp Toxicol Pathol. 2006] PMID: 16427258 Tissue reaction to an implantable identification device in mice. [Toxicol Pathol. 1990] PMID: 2267501 Subcutaneous soft tissue tumours at the site of implanted microchips in mice. [Exp Toxicol Pathol. 1997] PMID: 9314053 NTP Toxicology and Carcinogenesis Studies of Phenolphthalein (CAS No. 77-09-8) in F344/N Rats and B6C3F1 Mice (Feed Studies). [Natl Toxicol Program Tech Rep Ser. 1996] PMID: 12579199 Toxicology
and Carcinogenesis Studies of 5,5-Diphenylhydanto in (CAS No.
57-41-0) (Phenytoin) in F344/N Rats and B6C3F1 Mice (Feed Studies). [Natl
Toxicol Program Tech Rep Ser. 1993] PMID: 12621514 |
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Natural Nutrition and Holistic Healthcare For Cats & Dogs and People, too! (818) 707-6331 / Fax (818) 707-6333 www.celestialpets.com * celestialpet@sbcglobal.net |